-medial prefrontal cortex (vmPFC). Difficult moral decisions activated bilateral TPJ and deactivated the vmPFC and OFC. In contrast, easy moral decisions revealed patterns of activation in the vmPFC and deactivation in bilateral TPJ and dorsolateral PFC. Together these results suggest that moral cognition is a dynamic process implemented by a EnasidenibMedChemExpress AG-221 distributed network that involves interacting, yet functionally dissociable networks.Keywords: fMRI; moral; TPJ; vmPFCINTRODUCTION Over the past decade, neuroscientists exploring moral cognition have used brain imaging data to map a `moral network’ within the brain (Young and Dungan, 2011). This network encompasses circuits implicated in social, emotional and executive processes. For example, moral emotions appear to activate the limbic system (Shin et al., 2000) and temporal poles (Decety et al., 2011), while reasoned moral judgments reliably engage fronto-cortical areas (Berthoz et al., 2002; Heekeren et al., 2003; Kedia et al., 2008; Harenski et al., 2010). The distributed nature of the network reflects the fact that prototypical moral challenges recruit a broad spectrum of cognitive processes: inferring people’s intentions, integrating social norms, computing goal-directed actions, identifying with others and displaying empathic behavior (Moll et al., 2008). The initial focus within the research field was to explore whether moral decisions have a specific neural signature. This reflected the early dominance of neurocognitive models which argued for the unique properties of moral deliberation. One such theory endorsed the idea that we are endowed with an innate human moral faculty: our moral judgments are mediated by an unconscious mechanism which evaluates good vs bad (Hauser, 2006). Another theory suggested that moral choices are driven by intuitive emotions: in other words, we feel our way through knowing what is right and wrong (Haidt, 2001). However, as the imaging data accumulated, the theoretical emphasis shifted toward the view that the psychological processes underlying moral choices recruit socio-emotional and cognitive processes that are domain general (Moll et al., 2005). As opposed to a unique moral faculty, the evidence reflected the fact that moral choices reliably engage a delineated neural network which is also observed within the non-moral domain (Young and Dungan, 2011). In line with this view, one theory postulates that emotional processes and reason work in competition: controlled processes of cognition and automatic processes of emotion vie with each other to `work out’ a moral judgmentReceived 17 July 2012; APTO-253 supplier Accepted 24 November 2012 Advance Access publication 15 January 2013 Correspondence should be addressed to Oriel FeldmanHall, Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK. This research was supported by the Medical Research Council Cognition and Brain Sciences Unit. E-mail: [email protected](Greene et al., 2001). An alternative model suggests that reason and emotion do not act as competitive systems, but instead interact in a continuously integrated and parallel fashion (Moll et al., 2008). Reflecting this theoretical shift, more recent research efforts have used experimental probes to fractionate the moral network into constituent parts and illustrate relative dissociations. That is, distinct regions of the broad moral network are responsible for different putative components of moral cognition, an.-medial prefrontal cortex (vmPFC). Difficult moral decisions activated bilateral TPJ and deactivated the vmPFC and OFC. In contrast, easy moral decisions revealed patterns of activation in the vmPFC and deactivation in bilateral TPJ and dorsolateral PFC. Together these results suggest that moral cognition is a dynamic process implemented by a distributed network that involves interacting, yet functionally dissociable networks.Keywords: fMRI; moral; TPJ; vmPFCINTRODUCTION Over the past decade, neuroscientists exploring moral cognition have used brain imaging data to map a `moral network’ within the brain (Young and Dungan, 2011). This network encompasses circuits implicated in social, emotional and executive processes. For example, moral emotions appear to activate the limbic system (Shin et al., 2000) and temporal poles (Decety et al., 2011), while reasoned moral judgments reliably engage fronto-cortical areas (Berthoz et al., 2002; Heekeren et al., 2003; Kedia et al., 2008; Harenski et al., 2010). The distributed nature of the network reflects the fact that prototypical moral challenges recruit a broad spectrum of cognitive processes: inferring people’s intentions, integrating social norms, computing goal-directed actions, identifying with others and displaying empathic behavior (Moll et al., 2008). The initial focus within the research field was to explore whether moral decisions have a specific neural signature. This reflected the early dominance of neurocognitive models which argued for the unique properties of moral deliberation. One such theory endorsed the idea that we are endowed with an innate human moral faculty: our moral judgments are mediated by an unconscious mechanism which evaluates good vs bad (Hauser, 2006). Another theory suggested that moral choices are driven by intuitive emotions: in other words, we feel our way through knowing what is right and wrong (Haidt, 2001). However, as the imaging data accumulated, the theoretical emphasis shifted toward the view that the psychological processes underlying moral choices recruit socio-emotional and cognitive processes that are domain general (Moll et al., 2005). As opposed to a unique moral faculty, the evidence reflected the fact that moral choices reliably engage a delineated neural network which is also observed within the non-moral domain (Young and Dungan, 2011). In line with this view, one theory postulates that emotional processes and reason work in competition: controlled processes of cognition and automatic processes of emotion vie with each other to `work out’ a moral judgmentReceived 17 July 2012; Accepted 24 November 2012 Advance Access publication 15 January 2013 Correspondence should be addressed to Oriel FeldmanHall, Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK. This research was supported by the Medical Research Council Cognition and Brain Sciences Unit. E-mail: [email protected](Greene et al., 2001). An alternative model suggests that reason and emotion do not act as competitive systems, but instead interact in a continuously integrated and parallel fashion (Moll et al., 2008). Reflecting this theoretical shift, more recent research efforts have used experimental probes to fractionate the moral network into constituent parts and illustrate relative dissociations. That is, distinct regions of the broad moral network are responsible for different putative components of moral cognition, an.