Product Name :
Rabbit anti Human Neurogenin-1
Description :
| Isotype IgG | Product Type Antigen Immunoaffinity Purified Polyclonal | Units 100 µg | Host Rabbit | Species Reactivity Human | Application Enzyme Immunoassay Immunohistochemistry Western Blotting
Background :
Immunogen: Synthetic peptide derived from human neurogenin-1 protein.
Source :
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5′-CANNTG-3′). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Efficient DNA binding requires dimerization with another bHLH protein. Expression restricted to the embryonic nervous system. Synonyms: Class A basic helix-loop-helix protein 6; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation factor 3; NeuroD3; bHLHa6; NGN-1 <
Product :
Product Form: Affinity Purified Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Antigen Immunoaffiinity Purification Concentration: See vial for concentration
Specificity :
Applications :
Antibody can be used for immunohistochemical staining (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Immunohistochemistry
Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Ship at ambient temperature, freeze upon arrival
Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.
References :
1. Velkey, J.M., et al. ‘Expression of Neurogenin 1 in Mouse Embryonic Stem Cells Directs the Differentiation of Neuronal Precursors and Identifies Unique Patterns of Down-stream Gene Expression.’ Dev. Dyn., 242, 230-253 (2013) 2. Hill, G.W., et al. ‘Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.’ Stem Cells Dev., 21, 2827-2837 (2012) 3. Choi, C.I., et al. ‘Neural Induction with Neurogenin 1 Enhances the Therapeutic Potential of Mesenchymal Stem Cells in an ALS Mouse Model.’ Cell Transplant., Epub ahead of print (2012)
Related websites: https://www.medchemexpress.com/antibodies.html
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