Product Name :
Rabbit anti Human PINK1
Description :
| Isotype IgG | Product Type Antigen Immunoaffinity Purified Polyclonal | Units 100 µg | Host Rabbit | Species Reactivity Human | Application Enzyme Immunoassay Immunohistochemistry Western Blotting
Background :
Immunogen: Synthetic peptide derived from the human PINK1 protein. Control for antibody to G309D mutant (Cat. No. X2761P)
Source :
Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep. Synonyms: PTEN-induced putative kinase protein 1 <
Product :
Product Form: Affinity Purified Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Antigen Immunoaffiinity Purification Concentration: See vial for concentration
Specificity :
Applications :
Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Western Blotting
Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Ship at ambient temperature, freeze upon arrival
Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.
References :
1. Matsuda, N., et al. ‘PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.’ J. Cell. Biol., 189, 211-221 (2010) 2. Vives-Bauza, C., et al. ‘PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.’ Proc. Natl. Acad. Sci. USA, 107, 378-383 (2010) 3. Valente, E.M., et al. ‘PINK1 mutations are associated with sporadic early-onset parkinsonism.’ Ann. Neurol., 56, 336-341 (2004) 4. Geisler, S., et al. ‘The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.’ Autophagy, 6, 871-878 (2010) 5. Valente, E.M., et al. ‘Hereditary early-onset Parkinson’s disease caused by mutations in PINK1.’ Science, 304, 1158-1160 (2004) 6. Silvestri, L., et al. ‘Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.’ Hum. Mol. Genet., 14, 3477-3492 (2005)
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Elotuzumab
Histone H2A.X Antibody
Ubiquitin D Antibody: Ubiquitin D Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 18 kDa, targeting to Ubiquitin D. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.