Product Name :
Sheep anti Mouse Disabled-1 (CT)
Description :
| Isotype IgG | Product Type Polyclonal Antibody | Units 250 µg | Host Sheep | Species Reactivity Mouse | Application Immunoprecipitation Western Blotting
Background :
Immunogen: Recombinant protein corresponding to amino acids 399-555 of mouse disabled coupled to a GST fusion protein.
Source :
Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled Ð1 acts downstream of reelin in a signalling pathway. Synonyms: Disabled homolog 1; DAB1 <
Product :
Product Form: Unconjugated Formulation: Provided as a 0.2um sterile filter solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Ammonium Sulfate Precipitation Concentration: See vial for concentration
Specificity :
Applications :
Immunoblotting at 1 µg/ml, Immunoprecipitation at 5µg/ml. Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Western Blotting Positive Control: 293 cells transfected with Dab-1–HA tag
Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Room Temperature
Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.
References :
1.Homayouni,R. et.al (1999) J. Neuroscience 19(17), 7505-7515 2.Rice,d.s. et.al. (1998) Development 125 ,3710-3729
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