Product Name :
S 3304
Description:
S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.
CAS:
203640-27-1
Molecular Weight:
464.56
Formula:
C24H20N2O4S2
Chemical Name:
(2R)-3-(1H-indol-3-yl)-2-5-[2-(4-methylphenyl)ethynyl]thiophene-2-sulfonamidopropanoic acid
Smiles :
CC1C=CC(=CC=1)C#CC1=CC=C(S1)S(=O)(=O)N[C@H](CC1=CNC2C=CC=CC=21)C(O)=O
InChiKey:
YWCLDDLVLSQGSZ-JOCHJYFZSA-N
InChi :
InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Methotrexate Purity & Documentation
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.|Product information|CAS Number: 203640-27-1|Molecular Weight: 464.56|Formula: C24H20N2O4S2|Chemical Name: (2R)-3-(1H-indol-3-yl)-2-5-[2-(4-methylphenyl)ethynyl]thiophene-2-sulfonamidopropanoic acid|Smiles: CC1C=CC(=CC=1)C#CC1=CC=C(S1)S(=O)(=O)N[C@H](CC1=CNC2C=CC=CC=21)C(O)=O|InChiKey: YWCLDDLVLSQGSZ-JOCHJYFZSA-N|InChi: InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 83.3 mg/mL (179.31 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Hemocyanin In stock |Shelf Life: ≥12 months if stored properly.PMID:32880677 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors.|In Vivo:|In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen.|Products are for research use only. Not for human use.|