Product Name :
Rabbit anti-IRGM Polyclonal Antibody(C-term)
Synonym :
Immunity-related GTPase family M protein; 365-; Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 2647 macrophage protein 47 homolog; LRG-47; IRGM; IFI1; IRGM1; LRG47
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This IRGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the C-terminal region of human IRGM.
Predicted Reactivity:
Applications :
WB~~1:1000IHC-P~~1:10~50
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cancer;Cardiovascular;Immunology;Metabolism;Signal Transduction
Background :
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
UniProt :
A1A4Y4
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Immunity-related GTPase family M protein; 365-; Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 2647 macrophage protein 47 homolog; LRG-47; IRGM; IFI1; IRGM1; LRG47 |Host Rabbit |Specificity This IRGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the C-terminal region of human IRGM. |Species Reactivity Human |Applications WB~~1:1000IHC-P~~1:10~50 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cancer;Cardiovascular;Immunology;Metabolism;Signal Transduction |Target |Background Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). |Cellular localization Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. |UniProt A1A4Y4 |References |References Che, N., et al. Clin. Chim. Acta 411 (21-22), 1645-1649 (2010) :Wolfkamp, S.C., et al. Eur J Gastroenterol Hepatol 22(8):933-937(2010)Latiano, A., et al. Inflamm. Bowel Dis. 16(7):1108-1117(2010)Prescott, N.J., et al. Hum. Mol. Genet. 19(9):1828-1839(2010)Bekpen, C., et al. PLoS Genet. 5 (3), E1000403 (2009) : |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-IRGM Polyclonal Antibody(C-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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