Product Name :
Sheep anti Human Vesicle Associated Membrane Protein (VAMP 1/2)
Description :
| Isotype IgG | Product Type Polyclonal Antibody | Units 250 µg | Host Sheep | Species Reactivity Human Rat | Application Immunoprecipitation Western Blotting
Background :
Immunogen: Full length VAMP1/2 protein
Source :
Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated. Synonyms: Sheep anti vesicle associated membrane protein 1 and 2, VAMP 1 and 2, VAMP1/2, VAMP 1/2, VAMP-1/2; Synaptobrevin 1 and 2 <
Product :
Product Form: Unconjugated Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Ammonium Sulfate Precipitation Concentration: See vial for concentration
Specificity :
Applications :
Applications: Western Blotting, Immunoprecipitation Functional Analysis: Western Blotting
Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Room Temperature
Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.
References :
1. Moreno, J.A., et al. Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature (2012), 485, 507-511
Related websites: https://www.medchemexpress.com/antibodies.html
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