Product Name :
Shikonin
Description:
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
CAS:
517-89-5
Molecular Weight:
288.30
Formula:
C16H16O5
Chemical Name:
5, 8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-en-1-yl]-1, 4-dihydronaphthalene-1, 4-dione
Smiles :
CC(C)=CC[C@@H](O)C1=CC(=O)C2=C(C1=O)C(O)=CC=C2O
InChiKey:
NEZONWMXZKDMKF-SNVBAGLBSA-N
InChi :
InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Shikonin is a major component of a Chinese herbal medicine named zicao.Roflumilast manufacturer Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.Inavolisib manufacturer 5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.|Product information|CAS Number: 517-89-5|Molecular Weight: 288.30|Formula: C16H16O5|Synonym:|Isoarnebin 4|C.I. 75535|Chemical Name: 5, 8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-en-1-yl]-1, 4-dihydronaphthalene-1, 4-dione|Smiles: CC(C)=CC[C@@H](O)C1=CC(=O)C2=C(C1=O)C(O)=CC=C2O|InChiKey: NEZONWMXZKDMKF-SNVBAGLBSA-N|InChi: InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 31 mg/mL (107.53 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Shikonin is an inhibitor of TMEM16A chloride channel with an IC50 of 6.PMID:32962453 5 μM. Shikonin is also a specific inhibitor of PKM2and can also inhibit tumor necrosis factor-α (TNF-α) and prevent activation of nuclear factor-κB (NF-κB) pathway. Shikonin at concentrations higher than 50 μM significantly inhibits ormal human keratinocytes (NHKs) viability, compare with that of control (PIn Vivo:|Shikonin significantly inhibits the increase in IL-1β and TNF-α expression levels in the rat model of osteoarthritis, compare with those in the osteoarthritis group (PReferences:|Jiang Y et al. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea. Front Pharmacol. 2016 Aug 23;7:270.Li W, et al. Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation. PLoS One. 2015 May 11;10(5):e0126459.Yan Y, et al. Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasome Inhibition In Vitro. Chin Med J (Engl). 2015 Aug 20;128(16):2228-33.Products are for research use only. Not for human use.|