Product Name :
YM-298198 hydrochloride

Description:
YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders.

CAS:
1216398-09-2

Molecular Weight:
378.92

Formula:
C18H23ClN4OS

Chemical Name:
11-amino-N-cyclohexyl-N,3-dimethyl-5-thia-2,7-diazatricyclo[6.4.0.0²,⁶]dodeca-1(8),3,6,9,11-pentaene-4-carboxamide hydrochloride

Smiles :
Cl.CN(C1CCCCC1)C(=O)C1SC2=NC3C=CC(N)=CC=3N2C=1C

InChiKey:
WYTJVUVCSUWZTH-UHFFFAOYSA-N

InChi :
InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders.|Product information|CAS Number: 1216398-09-2|Molecular Weight: 378.92|Formula: C18H23ClN4OS|Chemical Name: 11-amino-N-cyclohexyl-N,3-dimethyl-5-thia-2,7-diazatricyclo[6.4.0.0²,⁶]dodeca-1(8),3,6,9,11-pentaene-4-carboxamide hydrochloride|Smiles: Cl.CN(C1CCCCC1)C(=O)C1SC2=NC3C=CC(N)=CC=3N2C=1C|InChiKey: WYTJVUVCSUWZTH-UHFFFAOYSA-N|InChi: InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Ceralasertib Epigenetic Reader Domain |Shelf Life: ≥12 months if stored properly.Treprostinil site |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32856591 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|YM-298198 hydrochloride shows a high affinity for mGluR1 with a Ki of 19 nM for rat mGluR1-NIH membranes. YM-298198 hydrochloride inhibits glutamate-induced inositol phosphate production in mGluR1-NIH3T3 cells, with an IC50 of 16 nM. YM-298198 hydrochloride shows neither agonistic nor antagonistic activity on mGluR2, 3, 4a, 6, or 7b up to 10 μM.|In Vivo:|YM-298198 hydrochloride (30 mg/kg; p.o.) shows a significant analgesic effect in streptozotocin-induced hyperalgesic mice.|Products are for research use only. Not for human use.|

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