Product Name :
G-1
Description:
G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.
CAS:
881639-98-1
Molecular Weight:
412.28
Formula:
C21H18BrNO3
Chemical Name:
1-[(3aS,4R,9bR)-4-(6-bromo-2H-1,3-benzodioxol-5-yl)-3H,3aH,4H,5H,9bH-cyclopenta[c]quinolin-8-yl]ethan-1-one
Smiles :
CC(=O)C1=CC2[C@@H]3C=CC[C@@H]3[C@@H](NC=2C=C1)C1=CC2OCOC=2C=C1Br
InChiKey:
VHSVKVWHYFBIFJ-HKZYLEAXSA-N
InChi :
InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3/t13-,14+,21-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.CTEP Cancer |Product information|CAS Number: 881639-98-1|Molecular Weight: 412.28|Formula: C21H18BrNO3|Chemical Name: 1-[(3aS,4R,9bR)-4-(6-bromo-2H-1,3-benzodioxol-5-yl)-3H,3aH,4H,5H,9bH-cyclopenta[c]quinolin-8-yl]ethan-1-one|Smiles: CC(=O)C1=CC2[C@@H]3C=CC[C@@H]3[C@@H](NC=2C=C1)C1=CC2OCOC=2C=C1Br|InChiKey: VHSVKVWHYFBIFJ-HKZYLEAXSA-N|InChi: InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3/t13-,14+,21-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (121.28 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Icotinib In Vivo |Shelf Life: ≥12 months if stored properly.PMID:32627622 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM. Treatment with G-1 (10 μM and 100 μM) for 48 and 72 h significantly decreases cell proliferation (PIn Vivo:|The results at 14 days post-injury show that the Basso mouse scale (BMS) scores are significantly higher in the G-1 group compared with the other groups (P0.05). G-1 administration produces a statistically significant decrease in tumor volume from day 14 post treatment. Grafted tumors harvested after three-week treatment with G-1 show a significant decrease in tumor weight compare to vehicle treated animals.|Products are for research use only. Not for human use.|